Prediction of prognosis, immune infiltration and immunotherapy response with N6-methyladenosine-related lncRNA clustering patterns in cervical cancer.

ABSTRACT: LncRNAs and tumor microenvironment (TME) exert an important effect in antitumor immunity. Nonetheless, the role of m⁶A-related lncRNA clustering patterns in prognosis, TME and immunotherapy of cervical cancer (CC) remains unknown. Here, based on 7 m⁶A-related prognostic lncRNAs obtained from TCGA-CC dataset, two m⁶AlncRNA clustering patterns were determined. m⁶AlncRNA clusterA was characterized by immune cell infiltrates and immune activation. m⁶AlncRNA clusterB was characterized by enrichment of immune evasion and tumorigenic activation pathways as well as survival and clinical stage disadvantage. Then, principal component analysis algorithms were used to construct m⁶AlncRNAscore based on prognostic differentially expressed

SUBMITTER: Jia H 

PROVIDER: S-EPMC9568557 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature