Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies.

ABSTRACT: While radiomics analysis has been applied for localized cancer disease, its application to the metastatic setting involves a non-exhaustive lesion subsampling strategy which may sidestep the intrapatient tumoral heterogeneity, hindering the reproducibility and the therapeutic response performance. Our aim was to evaluate if radiomics features can capture intertumoral intrapatient heterogeneity, and the impact of tumor subsampling on the computed heterogeneity. To this end, We delineated and extracted radiomics features of all visible tumors from single acquisition pre-treatment computed tomography of patients with metastatic lung cancer (cohort L) and confirmed our results on a larger cohort of patients with metastatic melanoma (cohort M). To quantify the captured heterogeneity, the absolu

SUBMITTER: Henry T 

PROVIDER: S-EPMC9568579 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature