Disentangling nigral and putaminal contribution to motor impairment and levodopa response in Parkinson's disease.

ABSTRACT: The extent to which the degeneration of the substantia nigra (SN) and putamen each contribute to motor impairment in Parkinson's disease (PD) is unclear, as they are usually investigated using different imaging modalities. To examine the pathophysiological significance of the SN and putamen in both motor impairment and the levodopa response in PD using diffusion microstructure imaging (DMI). In this monocentric retrospective cross-sectional study, DMI parameters from 108 patients with PD and 35 healthy controls (HC) were analyzed using a voxel- and region-based approach. Linear models were applied to investigate the association between individual DMI parameters and Movement Disorder Society Unified Parkinson's Disease Rating Scale-Part 3 performance in ON- and OFF-states, as well as the le

SUBMITTER: Schroter N 

PROVIDER: S-EPMC9568583 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature