Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children.

ABSTRACT: Leptin influences eating behavior. Exposure to early adversity is associated with eating behaviour disorders and metabolic syndrome, but the role of the leptin receptor on this relationship is poorly explored. We investigated whether individual differences in brain region specific leptin receptor (LepR) gene networks could moderate the effects of early adversity on eating behavior and metabolism. We created an expression-based polygenic risk score (ePRS) reflecting variations in the function of LepR gene network in prefrontal cortex and hypothalamus to investigate the interactions between a cumulative index of postnatal adversity on eating behavior in two independent birth cohorts (MAVAN and GUSTO). To explore whether variations in the prefrontal cortex or hypothalamic genetic scores could

SUBMITTER: de Lima RMS 

PROVIDER: S-EPMC9568584 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature