DNA methylation at birth in monozygotic twins discordant for pediatric acute lymphoblastic leukemia.

ABSTRACT: Aberrant DNA methylation constitutes a key feature of pediatric acute lymphoblastic leukemia at diagnosis, however its role as a predisposing or early contributor to leukemia development remains unknown. Here, we evaluate DNA methylation at birth in 41 leukemia-discordant monozygotic twin pairs using the Illumina EPIC array on archived neonatal blood spots to identify epigenetic variation associated with development of pediatric acute lymphoblastic leukemia, independent of genetic influence. Through conditional logistic regression we identify 240 significant probes and 10 regions associated with the discordant onset of leukemia. We identify a significant negative coefficient bias, indicating DNA hypomethylation in cases, across the array and enhanced in open sea, shelf/shore, and gene body

SUBMITTER: Nickels EM 

PROVIDER: S-EPMC9568651 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature