Disrupted methylation patterns at birth persist in early childhood: a prospective cohort analysis.

ABSTRACT:

Background

Alterations in the epigenome are a risk factor in multiple disease states. We have demonstrated in the past that disruption of the epigenome during early pregnancy or periconception, as demonstrated by altered methylation, may be associated with both assisted reproductive technology and undesirable clinical outcomes at birth, such as low birth weight. We have previously defined this altered methylation, calculated based on statistical upper and lower limits of outlier CpGs compared to the population, as an 'outlier methylation phenotype' (OMP). Our aim in this study was to determine whether children thus identified as possessing an OMP at birth by DNA methylation in cord blood persist as outliers in early childhood based on salivary DNA methylation.

Results

A tota

SUBMITTER: Dolinko AV 

PROVIDER: S-EPMC9568969 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature