Toxicokinetic study following intratracheal instillation or oral gavage of two [⁷Be]-tagged carbon black samples.

ABSTRACT:

Background

The toxicokinetic behaviour of nanostructured particles following pulmonary or oral deposition is of great scientific interest. In this toxicokinetic study, following the general principles of OECD TG 417, the systemic availability of carbon black, a nanostructured material consisting of agglomerated aggregates was characterised.

Methods

Each of two grades of beryllium-7 labelled carbon black (Monarch® 1000, oxidized and Printex® 90; untreated) was administered either intratracheally or orally to adult rats. Independent of route, rats received a single dose of approximately 0.3 mg radiolabelled carbon black. A total of 12 rats were treated per grade and per exposure route: 4 females each for feces/urine/organs and serial blood kinetics; 4 males for organs. At necr

SUBMITTER: Creutzenberg O 

PROVIDER: S-EPMC9569049 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature