Co-expression network analysis identifies potential candidate hub genes in severe influenza patients needing invasive mechanical ventilation.

ABSTRACT:

Background

Influenza is a contagious disease that affects people of all ages and is linked to considerable mortality during epidemics and occasional outbreaks. Moreover, effective immunological biomarkers are needed for elucidating aetiology and preventing and treating severe influenza. Herein, we aimed to evaluate the key genes linked with the disease severity in influenza patients needing invasive mechanical ventilation (IMV). Three gene microarray data sets (GSE101702, GSE21802, and GSE111368) from blood samples of influenza patients were made available by the Gene Expression Omnibus (GEO) database. The GSE101702 and GSE21802 data sets were combined to create the training set. Hub indicators for IMV patients with severe influenza were determined using differential expression ana

SUBMITTER: Chen L 

PROVIDER: S-EPMC9569050 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature