Expiratory high-frequency percussive ventilation: a novel concept for improving gas exchange.

ABSTRACT:

Background

Although high-frequency percussive ventilation (HFPV) improves gas exchange, concerns remain about tissue overdistension caused by the oscillations and consequent lung damage. We compared a modified percussive ventilation modality created by superimposing high-frequency oscillations to the conventional ventilation waveform during expiration only (eHFPV) with conventional mechanical ventilation (CMV) and standard HFPV.

Methods

Hypoxia and hypercapnia were induced by decreasing the frequency of CMV in New Zealand White rabbits (n = 10). Following steady-state CMV periods, percussive modalities with oscillations randomly introduced to the entire breathing cycle (HFPV) or to the expiratory phase alone (eHFPV) with varying amplitudes (2 or 4 cmH₂O) and frequ

SUBMITTER: Petak F 

PROVIDER: S-EPMC9569091 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature