Four Deep Brain Stimulation Targets for Obsessive-Compulsive Disorder: Are They Different?

ABSTRACT: Deep brain stimulation is a promising therapeutic approach for patients with treatment-resistant obsessive-compulsive disorder, a condition linked to abnormalities in corticobasal ganglia networks. Effective targets are placed in one of four subcortical areas with the goal of capturing prefrontal, anterior cingulate, and basal ganglia connections linked to the limbic system. These include the anterior limb of the internal capsule, the ventral striatum, the subthalamic nucleus, and a midbrain target. The goal of this review is to examine these 4 targets with respect to the similarities and differences of their connections. Following a review of the connections for each target based on anatomic studies in nonhuman primates, we examine the accuracy of diffusion magnetic resonance imaging trac

SUBMITTER: Haber SN 

PROVIDER: S-EPMC9569132 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature