Accurate characterization of dynamic microbial gene expression and growth rate profiles.

ABSTRACT: Genetic circuits are subject to variability due to cellular and compositional contexts. Cells face changing internal states and environments, the cellular context, to which they sense and respond by changing their gene expression and growth rates. Furthermore, each gene in a genetic circuit operates in a compositional context of genes which may interact with each other and the host cell in complex ways. The context of genetic circuits can, therefore, change gene expression and growth rates, and measuring their dynamics is essential to understanding natural and synthetic regulatory networks that give rise to functional phenotypes. However, reconstruction of microbial gene expression and growth rate profiles from typical noisy measurements of cell populations is difficult due to the effects

SUBMITTER: Vidal G 

PROVIDER: S-EPMC9569155 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature