TAZ is indispensable for c-MYC-induced hepatocarcinogenesis.

ABSTRACT:

Background & aims

Mounting evidence implicates the Hippo downstream effectors Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) in hepatocellular carcinoma (HCC). We investigated the functional contribution of YAP and/or TAZ to c-MYC-induced liver tumor development.

Methods

The requirement for YAP and/or TAZ in c-Myc-driven hepatocarcinogenesis was analyzed using conditional Yap, Taz, and Yap;Taz knockout (KO) mice. An hepatocyte-specific inducible TTR-CreER^T2 KO system was applied to evaluate the role of YAP and TAZ during tumor progression. Expression patterns of YAP, TAZ, c-MYC, and BCL2L12 were analyzed in human HCC samples.

Results

We found that the Hippo cascade is inactivated in c-Myc-induced mouse HCC. Intrig

SUBMITTER: Wang H 

PROVIDER: S-EPMC9569156 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature