Optimized tools and timing of response reassessment after neoadjuvant chemoradiation in rectal cancer.

ABSTRACT:

Purpose

Reassessment tools of response to long-course neoadjuvant chemoradiation treatment (nCRT) in patients with locally advanced rectal cancer (LARC) are important in predicting complete response (CR) and thus deciding whether a wait-and-watch strategy can be implemented in these patients. Choosing which routine reassessment tools are optimal and when to use them is still unclear and will be researched in the study.

Methods

Altogether, 250 patients with LARC who received nCRT from 2013 to 2021 and were followed up were retrospectively reviewed. Common reassessment tools of response included digital rectal examination (DRE), clinical examination and symptoms, endoscopy, biopsy, magnetic resonance imaging (MRI), and blood biomarkers.

Results

Overall, 27.20% (68/250)

SUBMITTER: Chen J 

PROVIDER: S-EPMC9569175 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature