Validation of an ovine vesicovaginal fistula model.

ABSTRACT:

Introduction and hypothesis

A representative, large animal model of vesicovaginal fistulas is needed for the training of surgeons and for the development of new surgical techniques and materials for obstetric fistula repair.

Methods

The safety, feasibility, and reproducibility of vesicovaginal fistula creation were studied in 4 adult female sheep. A 1-cm fistula was created between the vagina and the bladder through a transvaginal approach. The defect was allowed to heal for 8 weeks and the animals were then euthanized. The primary outcome was the fistula patency. Secondary outcomes were fistula size, urogenital dimensions, urodynamic evaluation, histology (inflammation, vascularization, collagen deposition) and biomechanical characteristics of the fistula edge (stress at br

SUBMITTER: Maljaars LP 

PROVIDER: S-EPMC9569284 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature