MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.

ABSTRACT:

Object

A large number of studies have suggested that stemness is an essential mechanism for drug resistance, metastasis and relapse in hepatocellular carcinoma (HCC). The aim of this study was to determine the impact of MCM2 on stemness and identify potential mechanisms that complement the stemness regulatory network in HCC.

Methods

MCM2 expression features and prognostic significance were analyzed in multiple cohorts, including TCGA LIHC dataset, GSE14520 dataset, Guangxi cohort, and GSE76427 dataset. Stemness-related molecules and phenotypes were examined to evaluate the impact of MCM2 on stemness. The expression levels of key molecules of the hippo signaling pathway together with downstream target genes were examined to evaluate the effect of MCM2 on hippo signaling. This

SUBMITTER: Zhou X 

PROVIDER: S-EPMC9569387 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature