Current Molecular Combination Therapies Used for the Treatment of Breast Cancer.

ABSTRACT: Breast cancer is the second leading cause of death for women worldwide. While monotherapy (single agent) treatments have been used for many years, they are not always effective, and many patients relapse after initial treatment. Moreover, in some patients the response to therapy becomes weaker, or resistance to monotherapy develops over time. This is especially problematic for metastatic breast cancer or triple-negative breast cancer. Recently, combination therapies (in which two or more drugs are used to target two or more pathways) have emerged as promising new treatment options. Combination therapies are often more effective than monotherapies and demonstrate lower levels of toxicity during long-term treatment. In this review, we provide a comprehensive overview of current combination t

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9569555 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature