Lactate-Lactylation Hands between Metabolic Reprogramming and Immunosuppression.

ABSTRACT: Immune evasion and metabolic reprogramming are two fundamental hallmarks of cancer. Interestingly, lactate closely links them together. However, lactate has long been recognized as a metabolic waste product. Lactate and the acidification of the tumor microenvironment (TME) promote key carcinogenesis processes, including angiogenesis, invasion, metastasis, and immune escape. Notably, histone lysine lactylation (Kla) was identified as a novel post-modification (PTM), providing a new perspective on the mechanism by which lactate functions and providing a promising and potential therapy for tumors target. Further studies have confirmed that protein lactylation is essential for lactate to function; it involves important life activities such as glycolysis-related cell functions and macrophage po

SUBMITTER: Chen L 

PROVIDER: S-EPMC9569569 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature