Postsynaptic Proteins at Excitatory Synapses in the Brain-Relationship with Depressive Disorders.

ABSTRACT: Depressive disorders (DDs) are an increasingly common health problem that affects all age groups. DDs pathogenesis is multifactorial. However, it was proven that stress is one of the most important environmental factors contributing to the development of these conditions. In recent years, there has been growing interest in the role of the glutamatergic system in the context of pharmacotherapy of DDs. Thus, it has become increasingly important to explore the functioning of excitatory synapses in pathogenesis and pharmacological treatment of psychiatric disorders (including DDs). This knowledge may lead to the description of new mechanisms of depression and indicate new potential targets for the pharmacotherapy of illness. An excitatory synapse is a highly complex and very dynamic structure,

SUBMITTER: Samojedny S 

PROVIDER: S-EPMC9569598 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature