Consequences of Autophagy Deletion on the Age-Related Changes in the Epidermal Lipidome of Mice.

ABSTRACT: Autophagy is a controlled mechanism of intracellular self-digestion with functions in metabolic adaptation to stress, in development, in proteostasis and in maintaining cellular homeostasis in ageing. Deletion of autophagy in epidermal keratinocytes does not prevent the formation of a functional epidermis and the permeability barrier but causes increased susceptibility to damage stress and metabolic alterations and accelerated ageing phenotypes. We here investigated how epidermal autophagy deficiency using Keratin 14 driven Atg7 deletion would affect the lipid composition of the epidermis of young and old mice. Using mass spectrometric lipidomics we found a reduction of age-related accumulation of storage lipids in the epidermis of autophagy-deficient mice, and specific changes in chain le

SUBMITTER: Yang Y 

PROVIDER: S-EPMC9569666 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature