Endoplasmic Reticulum Homeostasis Regulates TLR4 Expression and Signaling in Mast Cells.

ABSTRACT: The endoplasmic reticulum (ER) is a dynamic organelle that responds to demand in secretory proteins by undergoing expansion. The mechanisms that control the homeostasis of ER size and function involve the activation of the unfolded protein response (UPR). The UPR plays a role in various effector functions of immune cells. Mast cells (MCs) are highly granular tissue-resident cells and key drivers of allergic inflammation. Their diverse secretory functions in response to activation through the high-affinity receptor for IgE (FcεRI) suggest a role for the UPR in their function. Using human cord blood-derived MCs, we found that FcεRI triggering elevated the expression level and induced activation of the UPR transducers IRE1α and PERK, accompanied by expansion of the ER. In mouse bone marrow-de

SUBMITTER: Boukeileh S 

PROVIDER: S-EPMC9569687 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature