Assessment of DDAH1 and DDAH2 Contributions to Psychiatric Disorders via In Silico Methods.

ABSTRACT: The contribution of nitric oxide synthases (NOSs) to the pathophysiology of several neuropsychiatric disorders is recognized, but the role of their regulators, dimethylarginine dimethylaminohydrolases (DDAHs), is less understood. This study's objective was to estimate DDAH1 and DDAH2 associations with biological processes implicated in major psychiatric disorders using publicly accessible expression databases. Since co-expressed genes are more likely to be involved in the same biologic processes, we investigated co-expression patterns with DDAH1 and DDAH2 in the dorsolateral prefrontal cortex in psychiatric patients and control subjects. There were no significant differences in DDAH1 and DDAH2 expression levels in schizophrenia or bipolar disorder patients compared to controls. Meanwhile,

SUBMITTER: Kozlova AA 

PROVIDER: S-EPMC9569903 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature