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HOTAIR/miR-203/CAV1 Crosstalk Influences Proliferation, Migration, and Invasion in the Breast Cancer Cell.

ABSTRACT: In recent years, malignant breast cancer metastasis has caused a great increase in mortality. Research on the genetic and molecular mechanisms of malignant breast cancer has continued to deepen, and targeted therapy has become the general trend. Among them, competing endogenous RNA (ceRNA)-related molecules have received much attention. Homeobox transcript antisense RNA (HOTAIR) has been reported to function extensively as a ceRNA in breast cancer. Notably, miR-203 and Caveolin 1 (CAV1) have also been found to play a role in breast cancer. However, the relationship between the three remains unclear. In this study, we present a new mechanic through bioinformatics tool and basic experiments: the HOTAIR/miR-203/CAV1 axis, which complemented the role network of HOTAIR as a ceRNA, thus, it will provide a novel potential idea for breast cancer research and therapy.

SUBMITTER: Shi F 

PROVIDER: S-EPMC9569926 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature

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<i>HOTAIR/miR-203/CAV1</i> Crosstalk Influences Proliferation, Migration, and Invasion in the Breast Cancer Cell.

Shi Fuxiu F   Chen Xinyue X   Wang Yi Y   Xie Yujie Y   Zhong Junpei J   Su Kangtai K   Li Miao M   Li Yuqiu Y   Lin Qing Q   Zhou Youjia Y   Wang Jie J   Xiong Lixia L  

International journal of molecular sciences 20221004 19

In recent years, malignant breast cancer metastasis has caused a great increase in mortality. Research on the genetic and molecular mechanisms of malignant breast cancer has continued to deepen, and targeted therapy has become the general trend. Among them, competing endogenous RNA (ceRNA)-related molecules have received much attention. Homeobox transcript antisense RNA <i>(HOTAIR</i>) has been reported to function extensively as a ceRNA in breast cancer. Notably, <i>miR-203</i> and <i>Caveolin  ...[more]

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