Age-Associated Loss in Renal Nestin-Positive Progenitor Cells.

ABSTRACT: The decrease in the number of resident progenitor cells with age was shown for several organs. Such a loss is associated with a decline in regenerative capacity and a greater vulnerability of organs to injury. However, experiments evaluating the number of progenitor cells in the kidney during aging have not been performed until recently. Our study tried to address the change in the number of renal progenitor cells with age. Experiments were carried out on young and old transgenic nestin-green fluorescent protein (GFP) reporter mice, since nestin is suggested to be one of the markers of progenitor cells. We found that nestin⁺ cells in kidney tissue were located in the putative niches of resident renal progenitor cells. Evaluation of the amount of nestin⁺ cells in the k

SUBMITTER: Buyan MI 

PROVIDER: S-EPMC9569966 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature