Study of Biological Activities and ADMET-Related Properties of Salicylanilide-Based Peptidomimetics.

ABSTRACT: A series of eleven benzylated intermediates and eleven target compounds derived from salicylanilide were tested against Staphylococcus aureus ATCC 29213 and Enterococcus faecalis ATCC 29212 as reference strains and against three clinical isolates of methicillin-resistant S. aureus (MRSA) and three isolates of vancomycin-resistant E. faecalis. In addition, the compounds were evaluated against Mycobacterium tuberculosis H37Ra and M. smegmatis ATCC 700084. The in vitro cytotoxicity of the compounds was assessed using the human monocytic leukemia cell line THP-1. The lipophilicity of the prepared compounds was experimentally determined and correlated with biological activity. The benzylated intermediates were found to be completely biologically inactiv

SUBMITTER: Pindjakova D 

PROVIDER: S-EPMC9569995 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature