Selenium-Stimulated Exosomes Enhance Wound Healing by Modulating Inflammation and Angiogenesis.

ABSTRACT: Mesenchymal stem cell (MSC)-derived exosomes have emerged as an attractive cell-free tool in tissue engineering and regenerative medicine. The current study aimed to examine the anti-inflammatory, pro-angiogenic, and wound-repair effects of both exosomes and selenium-stimulated exosomes, and check whether the latter had superior wound healing capacity over others. The cellular and molecular network of exosomes, as a paracrine signal, was extensively studied by performing miRNA arrays to explore the key mediators of exosomes in wound healing. Selenium is known to play a critical role in enhancing the proliferation, multi-potency, and anti-inflammatory effects of MSCs. Selenium-stimulated exosomes showed significant effects in inhibiting inflammation and improving pro-angiogenesis in human u

SUBMITTER: Heo JS 

PROVIDER: S-EPMC9570007 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature