Development of a Hallmark Pathway-Related Gene Signature Associated with Immune Response for Lower Grade Gliomas.

ABSTRACT: Although some biomarkers have been used to predict prognosis of lower-grade gliomas (LGGs), a pathway-related signature associated with immune response has not been developed. A key signaling pathway was determined according to the lowest adjusted p value among 50 hallmark pathways. The least absolute shrinkage and selection operator (LASSO) and stepwise multivariate Cox analyses were performed to construct a pathway-related gene signature. Somatic mutation, drug sensitivity and prediction of immunotherapy analyses were conducted to reveal the value of this signature in targeted therapies. In this study, an allograft rejection (AR) pathway was considered as a crucial signaling pathway, and we constructed an AR-related five-gene signature, which can independently predict the prognosis of LG

SUBMITTER: Lai G 

PROVIDER: S-EPMC9570050 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature