Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testicular Function.

ABSTRACT: Aging is associated with testicular morphological and functional alterations, but the underlying molecular mechanisms and the impact of physical exercise are poorly understood. In this study, we examined the effects of age and lifelong moderate-intensity exercise on rat testis. Mature adults (35 weeks) and middle-aged (61 weeks) Wistar Unilever male rats were maintained as sedentary or subjected to a lifelong moderate-intensity treadmill training protocol. Testis weight and histology, mitochondrial biogenesis and function, and proteins involved in protein synthesis and stress response were evaluated. Our results illustrate an age-induced testicular atrophy that was associated with alterations in stress response, and mitochondrial biogenesis and function. Aging was associated with increased

SUBMITTER: Silva JV 

PROVIDER: S-EPMC9570257 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature