CTH/H₂S Regulates LPS-Induced Inflammation through IL-8 Signaling in MAC-T Cells.

ABSTRACT: Hydrogen sulfide (H₂S), as an endogenous gaseous signaling molecule, plays an important role in the inflammatory process. Our previous study found that Cystathionine-γ-lyase (CTH) and H₂S are correlated with the occurrence and development of Clinical Mastitis (CM) in Holstein cows. However, the functions and regulatory mechanisms of CTH/H₂S are still unknown. In this study, the inflammatory mammary cell model based on the MAC-T cell line was established by Lipopolysaccharide (LPS)-induced manner to further explore the function and regulatory mechanism of CTH/H₂S in cows with CM. In the inflammatory MAC-T cell, the CTH expression and H₂S production were both repressed in an LPS-dose dependent manner, which demonstrated that CTH/H_2<

SUBMITTER: Lin T 

PROVIDER: S-EPMC9570289 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature