Ontology highlight
ABSTRACT:
SUBMITTER: Goc YB
PROVIDER: S-EPMC9570295 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Göç Yavuz Burak YB Poziemski Jakub J Smolińska Weronika W Suwała Dominik D Wieczorek Grzegorz G Niedzialek Dorota D
International journal of molecular sciences 20220920 19
The initial aim of this work was to elucidate the mutual influence of different single-stranded segments (loops and caps) on the thermodynamic stability of RNA G-quadruplexes. To this end, we used a new NAB-GQ-builder software program, to construct dozens of two-tetrad G-quadruplex topologies, based on a designed library of sequences. Then, to probe the sequence-morphology-stability relationships of the designed topologies, we performed molecular dynamics simulations. Their results provide guida ...[more]