Italian Precision Medicine in Pediatric Oncology: Moving beyond Actionable Alterations.

ABSTRACT: Neuroblastoma (NB) is the most common extracranial solid tumor encountered in childhood. Although there has been significant improvement in the outcomes of patients with high-risk disease, the prognosis for patients with metastatic relapse or refractory disease is poor. Hence, the clinical integration of genome sequencing into standard clinical practice is necessary in order to develop personalized therapy for children with relapsed or refractory disease. The PeRsonalizEdMEdicine (PREME) project focuses on the design of innovative therapeutic strategies for patients suffering from relapsed NB. We performed whole exome sequencing (WES) of patient-matched tumor-normal samples to identify genetic variants amenable to precision medicine. Specifically, two patients were studied (First case: a t

SUBMITTER: Pastorino F 

PROVIDER: S-EPMC9570321 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature