Oocyte-Specific Knockout of Histone Lysine Demethylase KDM2a Compromises Fertility by Blocking the Development of Follicles and Oocytes.

ABSTRACT: The methylation status of histones plays a crucial role in many cellular processes, including follicular and oocyte development. Lysine-specific demethylase 2a (KDM2a) has been reported to be closely associated with gametogenesis and reproductive performance, but the specific function and regulatory mechanism have been poorly characterized in vivo. We found KDM2a to be highly expressed in growing follicles and oocytes of mice in this study. To elucidate the physiological role of Kdm2a, the zona pellucida 3-Cre (Zp3-Cre)/LoxP system was used to generate an oocyte Kdm2a conditional knockout (Zp3-Cre; Kdm2a^flox/flox, termed Kdm2a cKO) model. Our results showed that the number of pups was reduced by approximately 50% in adult <

SUBMITTER: Xiong X 

PROVIDER: S-EPMC9570323 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature