Transcriptome Analysis of Particulate Matter 2.5-Induced Abnormal Effects on Human Sebocytes.

ABSTRACT: Particulate matter 2.5 (PM_2.5), an atmospheric pollutant with an aerodynamic diameter of <2.5 μm, can cause serious human health problems, including skin damage. Since sebocytes are involved in the regulation of skin homeostasis, it is necessary to study the effects of PM_2.5 on sebocytes. We examined the role of PM_2.5 via the identification of differentially expressed genes, functional enrichment and canonical pathway analysis, upstream regulator analysis, and disease and biological function analysis through mRNA sequencing. Xenobiotic and lipid metabolism, inflammation, oxidative stress, and cell barrier damage-related pathways were enriched; additionally, PM_2.5 altered steroid hormone biosynthesis and retinol metabolism-related pathways. Con

SUBMITTER: Na HW 

PROVIDER: S-EPMC9570376 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature