A Novel Detection Method of Breast Cancer through a Simple Panel of Biomarkers.

ABSTRACT: Circulating tumor cells (CTCs) have been identified as responsible for the spread of tumors to other organs of the body. In this sense, the development of sensitive and specific assays for their detection is important to reduce the number of deaths due to metastases. Here, we assessed whether the detection of CTCs in peripheral blood can serve in the construction of a panel of diagnosis and monitoring treatments of breast cancer (BC), focusing on the expression of markers of epithelial-mesenchymal transition. Through analyzing the blood from women without breast alterations (control), women with benign alterations, women with breast cancer without chemotherapy, and women with breast cancer with chemotherapy, we identified the best markers by transcriptional levels and determined three prof

SUBMITTER: Silva ATF 

PROVIDER: S-EPMC9570447 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature