Respiratory Subsets in Patients with Moderate to Severe Acute Respiratory Distress Syndrome for Early Prediction of Death.

ABSTRACT:

Introduction

In patients with acute respiratory distress syndrome (ARDS), the PaO₂/FiO₂ ratio at the time of ARDS diagnosis is weakly associated with mortality. We hypothesized that setting a PaO₂/FiO₂ threshold in 150 mm Hg at 24 h from moderate/severe ARDS diagnosis would improve predictions of death in the intensive care unit (ICU).

Methods

We conducted an ancillary study in 1303 patients with moderate to severe ARDS managed with lung-protective ventilation enrolled consecutively in four prospective multicenter cohorts in a network of ICUs. The first three cohorts were pooled (n = 1000) as a testing cohort; the fourth cohort (n = 303) served as a confirmatory cohort. Based on the thresholds for PaO₂/FiO<

SUBMITTER: Villar J 

PROVIDER: S-EPMC9570540 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature