A Single Vitamin D₃ Bolus Supplementation Improves Vitamin D Status and Reduces Proinflammatory Cytokines in Healthy Females.

ABSTRACT: Vitamin D deficiency is a global health problem that not only leads to metabolic bone disease but also to many other illnesses, most of which are associated with chronic inflammation. Thus, our aim was to investigate the safety and effectiveness of a single high dose of vitamin D₃ (80,000 IU) on vitamin D status and proinflammatory cytokines such as interleukin (IL)6, IL8 and tumor necrosis factor (TNF) in healthy Saudi females. Fifty healthy females were recruited and orally supplemented with a single vitamin D₃ bolus (80,000 IU). All participants donated fasting blood samples at baseline, one day and thirty days after supplementation. Serum 25-hydroxyvitamin D₃ (25(OH)D₃), IL6, IL8, TNF, calcium, phosphate, parathyroid hormone (PTH) and blood l

SUBMITTER: Alsufiani HM 

PROVIDER: S-EPMC9570631 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature