Analysis of Sphingolipids in Pediatric Patients with Cholelithiasis-A Preliminary Study.

ABSTRACT: (1) Background: Disturbances in the sphingolipid profile are observed in many diseases. There are currently no data available on the evaluation of sphingolipids and ceramides in cholelithiasis in children. The aim of this study was to evaluate the concentrations of sphingolipids in the sera of pediatric patients with gallstones. We determined their relationship with anthropometric and biochemical parameters. (2) Methods: The concentrations of sphingolipids in serum samples were evaluated using a quantitative method, ultra-high-performance liquid chromatography-tandem mass spectrometry. (3) Results: The prospective study included 48 children and adolescents diagnosed with gallstones and 38 controls. Serum concentrations of total cholesterol (TC); sphinganine (SPA); ceramides-C14:0-Cer, C16:

SUBMITTER: Zdanowicz K 

PROVIDER: S-EPMC9570855 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature