Identification of miRNAs Involved in Foetal Growth Restriction Due to Maternal Smoking during Pregnancy.

ABSTRACT:

Introduction

Smoking during pregnancy is associated with reduced foetal growth, amongst other effects. Epigenetic modification in the foetus and placenta during embryonic development as a result of changes in the function of miRNAs is one of the pathophysiological mechanisms responsible for this. This dysregulation may be due to environmental changes or toxins such as tobacco.

Objective

To study the impact of smoking during pregnancy and its role in intrauterine growth restriction via hypermethylated miRNAs.

Materials and methods

The differences in methylation patterns for miRNAs in umbilical cord blood from low-birth-weight newborns of smoking mothers were compared with those from normal-weight newborns using MedIP-seq (StarArray).

Results

Seven hypermethylate

SUBMITTER: Barrio E 

PROVIDER: S-EPMC9571148 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature