L-Cysteine Modified Chitosan Nanoparticles and Carbon-Based Nanostructures for the Intranasal Delivery of Galantamine.

ABSTRACT: The present study evaluates the use of thiolized chitosan conjugates (CS) in combination with two fundamental carbon nanoforms (carbon dots (CDs) and Hierarchical Porous Carbons (HPC)) for the preparation of intranasally (IN) administrated galantamine (GAL) nanoparticles (NPs). Initially, the modification of CS with L-cysteine (Cys) was performed, and the successful formation of a Cys-CS conjugates was verified via ¹H-NMR, FTIR, and pXRD. The new Cys-CS conjugate showed a significant solubility enhancement in neutral and alkaline pH, improving CS's utility as a matrix-carrier for IN drug administration. In a further step, drug-loaded NPs were prepared via solid-oil-water double emulsification, and thoroughly analyzed by SEM, DLS, FTIR and pXRD. The results showed the formation o

SUBMITTER: Nanaki SG 

PROVIDER: S-EPMC9571213 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature