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PH-Responsive Inorganic/Organic Nanohybrids System for Controlled Nicotinic Acid Drug Release.

ABSTRACT: Although nicotinic acid (NA) has several clinical benefits, its potency cannot be fully utilized due to several undesirable side effects, including cutaneous flushing, GIT-associated symptoms, etc. To overcome such issues and improve the NA efficacy, a new inorganic-organic nanohybrids system was rationally designed. For making such a hybrid system, NA was intercalated into LDH through a coprecipitation technique and then coated with Eudragit^® S100 to make the final drug delivery system called Eudragit^® S100-coated NA-LDH. The as-made drug delivery system not only improved the NA release profile but also exhibited good bio-compatibility as tested on L929 cells. Such an inorganic-organic nanohybrid drug delivery agent is expected to reduce the undesirable side effects associated with NA and hopefully improve the pharmacological effects without inducing any undesirable toxicity.

SUBMITTER: Yu S

PROVIDER: S-EPMC9571272 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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pH-Responsive Inorganic/Organic Nanohybrids System for Controlled Nicotinic Acid Drug Release.

Yu Seungjin S Piao Huiyan H Rejinold N Sanoj NS Lee Hanna H Choi Goeun G Choy Jin-Ho JH

Molecules (Basel, Switzerland) 20220929 19

Although nicotinic acid (NA) has several clinical benefits, its potency cannot be fully utilized due to several undesirable side effects, including cutaneous flushing, GIT-associated symptoms, etc. To overcome such issues and improve the NA efficacy, a new inorganic-organic nanohybrids system was rationally designed. For making such a hybrid system, NA was intercalated into LDH through a coprecipitation technique and then coated with Eudragit<sup>®</sup> S100 to make the final drug delivery syst ...[more]

PMID: 36234976

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