PH-Responsive Inorganic/Organic Nanohybrids System for Controlled Nicotinic Acid Drug Release.

ABSTRACT: Although nicotinic acid (NA) has several clinical benefits, its potency cannot be fully utilized due to several undesirable side effects, including cutaneous flushing, GIT-associated symptoms, etc. To overcome such issues and improve the NA efficacy, a new inorganic-organic nanohybrids system was rationally designed. For making such a hybrid system, NA was intercalated into LDH through a coprecipitation technique and then coated with Eudragit^® S100 to make the final drug delivery system called Eudragit^® S100-coated NA-LDH. The as-made drug delivery system not only improved the NA release profile but also exhibited good bio-compatibility as tested on L929 cells. Such an inorganic-organic nanohybrid drug delivery agent is expected to reduce the undesirable side effects

SUBMITTER: Yu S 

PROVIDER: S-EPMC9571272 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature