Association between Urolithiasis and History Proton Pump Inhibitor Medication: A Nested Case-Control Study.

ABSTRACT: A few retrospective studies have suggested the risk of urolithiasis associated with the use of proton pump inhibitors (PPIs). The current research intended to estimate the risk of urolithiasis according to previous PPI use. A nested case-control study was conducted using the National Health Insurance Service-National Health Screening Cohort in Korea. A total of 28,962 patients with urolithiasis and 115,848 control participants were selected. The previous prescription history of PPI with days of PPI prescription was collected. To calculate the odds ratios (OR) of past, current, and days of PPI use for urolithiasis, logistic regression models were used. Subgroup analyses were conducted. The urolithiasis group demonstrated a higher rate of current PPI users than the control group (60.9% vs. 4

SUBMITTER: Kim SY 

PROVIDER: S-EPMC9571377 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature