TiSe₂-mediated sonodynamic and checkpoint blockade combined immunotherapy in hypoxic pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer remains among the most prevalent and aggressive forms of cancer. While immunotherapeutic treatment strategies have shown some promise in affected patients, the benefits of these interventions have been limited by insufficient tumor infiltration by activated T cells.

Results

Here, Titanium diselenide (TiSe₂) nanosheets were synthesized with good stability. When exposed to ultrasound (US), the TiSe₂ nanosheets served as a reliable nano-sensitizer capable of inducing large amounts of reactive oxygen species (ROS) mediating sonodynamic therapy (SDT) under hypoxic and normoxic conditions. The tumor-released TAAs induced by TiSe₂ nanosheet-mediated SDT promoted immunogenic cell death (ICD) conducive to the maturation of

SUBMITTER: Chen L 

PROVIDER: S-EPMC9571469 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature