Characterisation of ethnic differences in DNA methylation between UK-resident South Asians and Europeans.

ABSTRACT: Ethnic differences in non-communicable disease risk have been described between individuals of South Asian and European ethnicity that are only partially explained by genetics and other known risk factors. DNA methylation is one underexplored mechanism that may explain differences in disease risk. Currently, there is little knowledge of how DNA methylation varies between South Asian and European ethnicities. This study characterised differences in blood DNA methylation between individuals of self-reported European and South Asian ethnicity from two UK-based cohorts: Southall and Brent Revisited and Born in Bradford. DNA methylation differences between ethnicities were widespread throughout the genome (n = 16,433 CpG sites, 3.4% sites tested). Specifically, 76% of associations were attribut

SUBMITTER: Elliott HR 

PROVIDER: S-EPMC9571473 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature