Ontology highlight
ABSTRACT:
SUBMITTER: Brauser M
PROVIDER: S-EPMC9571696 | biostudies-literature | 2022 Sep
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20220926 19
Until now, the intermediate responsible for the acyl transfer of a highly enantioselective tetrapeptide organocatalyst for the kinetic resolution of trans-cycloalkane-1,2-diols has never been directly observed. It was proposed computationally that a π-methylhistidine moiety is acylated as an intermediate step in the catalytic cycle. In this study we set out to investigate whether we can detect and characterize this key intermediate using NMR-spectroscopy and mass spectrometry. Different mass spe ...[more]