Characterization of Polyphenolic Compounds from Bacopa procumbens and Their Effects on Wound-Healing Process.

ABSTRACT: Wounds represent a medical problem that contributes importantly to patient morbidity and to healthcare costs in several pathologies. In Hidalgo, Mexico, the Bacopa procumbens plant has been traditionally used for wound-healing care for several generations; in vitro and in vivo experiments were designed to evaluate the effects of bioactive compounds obtained from a B. procumbens aqueous fraction and to determine the key pathways involved in wound regeneration. Bioactive compounds were characterized by HPLC/QTOF-MS, and proliferation, migration, adhesion, and differentiation studies were conducted on NIH/3T3 fibroblasts. Polyphenolic compounds from Bacopa procumbens (PB) regulated proliferation and cell adhesion; enhanced migration, reducing the artificial scratch area;

SUBMITTER: Martinez-Cuazitl A 

PROVIDER: S-EPMC9571823 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature