Exploring the Complex Network of Heme-Triggered Effects on the Blood Coagulation System.

ABSTRACT: Excess labile heme, occurring under hemolytic conditions, displays a versatile modulator in the blood coagulation system. As such, heme provokes prothrombotic states, either by binding to plasma proteins or through interaction with participating cell types. However, despite several independent reports on these effects, apparently contradictory observations and significant knowledge gaps characterize this relationship, which hampers a complete understanding of heme-driven coagulopathies and the development of suitable and specific treatment options. Thus, the computational exploration of the complex network of heme-triggered effects in the blood coagulation system is presented herein. Combining hemostasis- and heme-specific terminology, the knowledge available thus far was curated and model

SUBMITTER: Mubeen S 

PROVIDER: S-EPMC9572022 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature