S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases.

ABSTRACT: Psoriasis is one of the most common inflammatory skin diseases affecting about 1-3% of the population. One of the characteristic abnormalities in psoriasis is the excessive production of antimicrobial peptides and proteins, which play an essential role in the pathogenesis of the disease. Antimicrobial peptides and proteins can be expressed differently in normal and diseased skin, reflecting their usefulness as diagnostic biomarkers. Moreover, due to their very important functions in innate immunity, members of host defense peptides and proteins are currently considered to be promising new therapeutic targets for many inflammatory diseases. Koebnerisin (S100A15) belongs to an S100 family of antimicrobial proteins, which constitute the multigenetic group of calcium-binding proteins involved

SUBMITTER: Kurpet K 

PROVIDER: S-EPMC9572071 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature