The Characteristics of Microbiome and Cytokines in Healthy Implants and Peri-Implantitis of the Same Individuals.

ABSTRACT:

Aim

To characterize the profile of submucosal microbiome and cytokine levels in peri-implant crevicular fluid (PICF) from clinically healthy implants and peri-implantitis in the same individuals.

Material and methods

A total of 170 patients were screened and, finally, 14 patients with at least one healthy implant and one peri-implantitis implant were included. Submucosal microbiota and cytokines from 28 implants were analyzed using 16S rRNA gene sequencing and multifactor assays, respectively. Correlations of clinical indexes and microbiota or cytokines were analyzed using Spearman's correlation coefficient. A random forest classification model was constructed.

Results

Peri-implantitis sites harbored higher microbial diversity, as well as more Gram-negative bacteria a

SUBMITTER: Song L 

PROVIDER: S-EPMC9572122 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature