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Nano-Theranostics Constructed from Terpyridine-Modified Pillar [5]arene-Based Supramolecular Amphiphile and Its Application in Both Cell Imaging and Cancer Therapy.

ABSTRACT: Theranostics play an important role in cancer treatment due to its realized real-time tracking of therapeutic efficacy in situ. In this work, we have designed and synthesized a terpyridine-modified pillar [5]arenes (TP5). By the coordination of terpyridine and Zn²⁺, the complex TP5/Zn was obtained. Then, supramolecular amphiphile can be constructed by using host-guest complexation between a polyethylene glycol contained guest (PM) and TP5/Zn. Combining the fluorescence properties from the terpyridine group and the amphiphilicity from the system, the obtained TP5/Zn/PM can further be self-assembled into fluorescent particles with diameters of about 150 nm in water. The obtained particles can effectively load anti-cancer drugs and realize living cell imaging and a precise release of the drugs.

SUBMITTER: Zhou Y

PROVIDER: S-EPMC9572324 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature

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Nano-Theranostics Constructed from Terpyridine-Modified Pillar [5]arene-Based Supramolecular Amphiphile and Its Application in Both Cell Imaging and Cancer Therapy.

Zhou Youjun Y Yang Lu L Ma Longtao L Han Ying Y Yan Chao-Guo CG Yao Yong Y

Molecules (Basel, Switzerland) 20220929 19

Theranostics play an important role in cancer treatment due to its realized real-time tracking of therapeutic efficacy in situ. In this work, we have designed and synthesized a terpyridine-modified pillar [5]arenes (TP5). By the coordination of terpyridine and Zn2+, the complex TP5/Zn was obtained. Then, supramolecular amphiphile can be constructed by using host-guest complexation between a polyethylene glycol contained guest (PM) and TP5/Zn. Combining the ...[more]

PMID: 36234963

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