Efficacy of Metformin as Adjuvant Therapy in Metastatic Breast Cancer Treatment.

ABSTRACT:

Background

Metformin has been reported to have an anti-tumorigenic impact against metastatic breast cancer (MBC) cells through several mechanisms. Its effect can be evaluated by using many variables such as the response rate (RR) as well as the progression-free survival (PFS).

Materials and methods

A prospective study was conducted to investigate and estimate the metformin effect on MBC. About 107 subjects were included in the study and were divided into two groups: Group A included non-diabetic MBC patients treated with metformin in conjunction with chemotherapy and group B included those treated with chemotherapy alone. Both PFS and RR were used as a criteria to evaluate the treatment outcome. Associated adverse effects of metformin were also assessed.

Results

The a

SUBMITTER: Essa NM 

PROVIDER: S-EPMC9572354 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature