Catheter Ablation versus Medical Therapy of Atrial Fibrillation in Patients with Heart Failure: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Atrial fibrillation (AF) and heart failure (HF) often coexist and synergistically contribute to an increased risk of hospitalization, stroke, and mortality.

Objective

To compare the efficacy of catheter ablation (CA) versus medical therapy (MT) in HF patients with AF.

Methods

Electronic databases were queried for randomized controlled trials (RCTs) of CA versus MT of AF in patients with HF. Risk ratios (RRs), mean differences (MDs), and 95% confidence intervals (CIs) were measured using the Mantel-Haenszel method.

Results

A total of nine RCTs enrolling 2155 patients met the inclusion criteria. Compared to MT, CA led to a significant reduction in the composite of all-cause mortality and HF hospitalization (24.6% vs. 37.1%; RR: 0.65 (95% CI: 0.53-0.80)

SUBMITTER: Magnocavallo M 

PROVIDER: S-EPMC9572511 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature